Fundamentals
Pathophysiology
Marfan syndrome results from mutations in the FBN1 gene encoding fibrillin-1, a glycoprotein essential for elastic fiber integrity. Defective fibrillin leads to dysregulated TGF-beta signaling, causing progressive aortic root dilation, mitral valve prolapse, and aortic dissection risk. The clinician must manage lifelong cardiovascular surveillance and determine timing for prophylactic surgery.
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Unlock the interactive lesson quiz with a plan that includes this WHNP pathway. You can still explore topic-filtered questions from the bank hubs below.
Unlock the interactive lesson quiz with a plan that includes this WHNP pathway. You can still explore topic-filtered questions from the bank hubs below.
