Pathophysiology
Clinical meaning
Heart-healthy dietary patterns reduce cardiovascular risk through multiple mechanisms including blood pressure reduction, lipid profile improvement, inflammation reduction, and endothelial function optimization. The DASH (Dietary Approaches to Stop Hypertension) diet emphasizes fruits, vegetables, whole grains, lean proteins, and low-fat dairy while limiting sodium to 1,500-2,300 mg/day. The Mediterranean diet rich in olive oil, fish, nuts, and whole grains has demonstrated significant reduction in cardiovascular events through anti-inflammatory and antioxidant effects. Sodium restriction reduces extracellular fluid volume and peripheral vascular resistance, lowering blood pressure by 5-8 mmHg. Dietary cholesterol and saturated fat intake directly affect LDL cholesterol levels and atherosclerotic plaque formation. Omega-3 fatty acids from fatty fish reduce triglycerides, inflammation, and arrhythmia risk.