Fundamentals
Pathophysiology
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity resulting from immature lung tissue exposed to supplemental oxygen and mechanical ventilation. Oxidative stress and barotrauma arrest alveolar and vascular development, leading to fewer, larger alveoli with thickened interstitium. This impairs gas exchange and increases work of breathing in the developing infant.
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